Burns et al4 have performed a metaanalysis of NIV weaning to facilitate liberation from mechanical ventilation. They have found that NIV was associated with lower mortality (risk ratio, 0.41), less ventilator-associated pneumonia (risk ratio, 0.28), and shorter mechanical ventilation (7.3 days), ICU stay (6.9 days), and hospital stay (7.3 days). NIV had no effect on the probability of weaning success. Recently, Burns et al5 updated their metaanalysis with new studies, totaling 227 patients with COPD with pneumonia, that randomized patients after they met criteria indicating control of pulmonary infection, rather than after failure to tolerate an SBT. In addition, some of these studies differed fundamentally from other studies in that the weaning mode was different in the two groups: NIV weaning was conducted with pressure support, whereas invasive weaning was performed with synchronized intermittent mandatory ventilation plus pressure support. With these caveats in mind, this metaanalysis of 12 studies and 530 patients, principally with COPD, showed that NIV weaning significantly reduced mortality (risk ratio, 0.55; 95% CI, 0.38-0.79), nosocomial pneumonia (risk ratio, 0.29; 95% CI, 0.19-0.45), ICU stay (weighted mean difference, 6.3 days), hospital stay (7.2 days), total duration of ventilation (5.6 days), and duration of invasive ventilation (7.8 days). NIV was associated with fewer tracheostomies.