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Original Research: SLEEP MEDICINE |

B-Type Natriuretic Peptide and Cardiovascular Function in Young Children With Obstructive Sleep Apnea

Aviv D. Goldbart, MD; Aviva Levitas, MD; Sari Greenberg-Dotan, PhD; Shalom Ben Shimol, MD; Arnon Broides, MD; Marc Puterman, MD; Asher Tal, MD
Author and Funding Information

From the Sleep Wake Disorders Unit (Drs Goldbart and Tal), the Department of Pediatrics (Drs Goldbart, Ben Shimol, Broides, and Tal), the Pediatric Cardiology Unit (Dr Levitas), the Department of Epidemiology (Dr Greenberg-Dotan), and the Department of Otolaryngology-Head and Neck Surgery (Dr Puterman), Soroka University Medical Center, Beer-Sheva, Israel.

Correspondence to: Aviv D. Goldbart, MD, Department of Pediatrics, Sleep Wake Disorder Unit, Soroka University Medical Center, Beer-Sheva, Israel; e-mail: avivgold@bgu.ac.il


Funding/Support: Dr Goldbart is supported by the Israel Science Foundation Legacy Program [Grant 1817/07].

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;138(3):528-535. doi:10.1378/chest.10-0150
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Objective:  N-terminal pro-B-type natriuretic peptide (NT-proBNP), a marker of ventricular strain, and C-reactive protein (CRP), a marker of inflammation, are reportedly elevated in school-aged children with obstructive sleep apnea (OSA). We hypothesized that cardiovascular morbidity affects circulating markers and their echocardiographic and polysomnographic (PSG) correlates in young children with OSA.

Methods:  We assessed young children undergoing adenotonsillectomy (TA) for OSA by polysomnography, echocardiography, and serum CRP and NT-proBNP levels.

Results:  A total of 90 children with OSA (mean age 19 ± 7 months; 71.2% male; BMI, z = 0.62 ± 1.04) and 45 age- and sex-matched controls were included. Three months following TA, 72 children were reassessed for NT-proBNP and CRP. NT-proBNP level (pg/mL) was higher in subjects with OSA (189.1 ± 112.7) vs control subjects (104.8 ± 49.5; P = .006). Both NT-proBNP (187.8 ± 114 vs 86 ± 32.6; P = .002) and CRP levels (mg %) (0.49 ± 0.41 vs 0.1 ± 0.17; P < .05) decreased following TA. Doppler pulse wave measuring tricuspid regurgitation (TR), a reflection of pulmonary hypertension, correlated with CRP (r = 0.61, P < .01) but not NT-proBNP (r = −0.14, P = .53) levels. Left ventricle end-diastolic diameter (LVEDD) was at the maximal normal range (0.91 ± 0.11), but did not correlate with CRP or NT-proBNP levels. Both CRP level and TR correlated with PSG variables reflecting nocturnal hypoxemia, whereas NT-proBNP level and LVEDD did not. Echocardiography in 40 children (out of 90) showed a decline in TR that was abnormal before TA and correlated with the decrease in CRP following TA.

Conclusions:  NT-proBNP levels are increased in children with OSA and decrease following TA. Echocardiographic parameters suggesting increased pulmonary pressure in young children with OSA are related to nocturnal hypoxemia and systemic inflammation, which also decrease following therapy

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