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Two Cases With Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Successfully Treated With Clarithromycin

Yuji Ishimatsu, MD, PhD; Hiroshi Mukae, MD, PhD; Kiyoshi Matsumoto, MD; Tatsuhiko Harada, MD; Atsuko Hara, MD; Shintaro Hara, MD; Misato Amenomori, MD; Hanako Fujita, MD; Noriho Sakamoto, MD, PhD; Tomayoshi Hayashi, MD, PhD; Shigeru Kohno, MD, PhD, FCCP
Author and Funding Information

From the Second Department of Internal Medicine (Drs Ishimatsu, Mukae, Harada, A. Hara, S. Hara, Amenomori, Fujita, Sakamoto, and Kohno), Nagasaki University School of Medicine, Nagasaki; the Division of Respiratory Disease (Dr Mukae), University of Occupational and Environmental Health, Kitakyushu; the Shimin-no-Mori Hospital (Dr Matsumoto), Miyazaki; and the Department of Pathology (Dr Hayashi), Nagasaki University Hospital, Nagasaki, Japan.

Correspondence to: Hiroshi Mukae, MD, PhD, Department of Respiratory Disease, School of Medicine, University of Occupational and Environmenal Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan 807-8555; e-mail: hmukae@med.uoeh-u.ac.jp


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;138(3):730-733. doi:10.1378/chest.09-2358
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A 70-year-old woman with a history of sinobronchial syndrome was admitted to the hospital because of a cough, sputum, and abnormal chest shadow. She was diagnosed with pulmonary mucosa-associated lymphoid tissue lymphoma (p-MALToma) based on results of a pathologic examination and the gene rearrangements in the Ig heavy chain on Southern blot hybridization. Although p-MALToma did not regress with conventional therapy, it was reduced after long-term treatment with clarithromycin (CAM) (200 mg/d). A 57-year-old woman with a history of Sjögren syndrome and lymphocytic interstitial pneumonia had a mass lesion in the left lower lung field. CT image-guided biopsy established a diagnosis of p-MALToma. The p-MALToma regressed with long-term treatment with CAM (200 mg/d), whereas Helicobacter pylori (HP) eradication therapy was not effective in concurrent atrophic gastritis with HP. It is suggested that CAM, a macrolide antibiotic, may be effective in some patients with p-MALToma.

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