First, we would like to thank the authors for their interest in our article.1 They raised a very interesting issue about a potential gender difference in an early time to initiation of an appropriate antimicrobial therapy that is known to be a crucial therapeutic strategy for improving survival in patients with severe sepsis. Conversely to the results of a previous Austrian study,2 we did not find any difference in the level of care between the sexes. However, we do agree that this particular issue could have been a potential confounder in our recently published article.1 Among the 1,608 men and women matched using our propensity score, 891 patients were appropriately treated right at the day of diagnosis (55%). Among them, 544 were men (54%) and 347 were women (57%). After conditional regression logistic analysis, early and appropriate antibiotherapy rate was not different between men and women (odds ratio, 1.12; 95% confidence interval, 0.91 to 1.38; p = 0.28). This clearly shows that early and appropriate therapy is not a confounder in our study and does not modify our message.