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Postgraduate Education Corner: PULMONARY AND CRITICAL CARE PEARLS |

A 29-Year-Old Woman With a Remote History of Osteosarcoma and Positron Emission Tomography-Positive Pleurally Based Masses

Aly M. Hemdan Abdalla, MB, BCh; Dorothy White, MD, FCCP
Author and Funding Information

*From the Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY.

Correspondence to: Aly M. Hemdan Abdalla, MB, BCh, Memorial Sloan-Kettering Cancer Center, Medicine, 1275 York Ave, New York, NY 10065; e-mail: hemdanaa@mskcc.org


The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).


Chest. 2008;134(3):640-643. doi:10.1378/chest.07-3068
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Extract

A 29 -year-old woman was referred for evaluation of pleurally based masses detected on a chest CT scan. She had received a diagnosis of lymphangioleiomyomatosis (LAM) at age 24 years when she presented with a large pneumothorax. Because of slowly progressive dyspnea on exertion and worsening of radiographic cystic changes, she was being considered for lung transplantation. In addition to dyspnea, she had a mild nonproductive cough but no chest pain, weight loss, fever, or night sweats. Her medical history included a diagnosis of osteosarcoma at age 7 years, which was treated with chemotherapy and an above-knee amputation of the right leg; renal insufficiency secondary to chemotherapy; and an angiolipoma. She had undergone bilateral talc pleurodesis for recurrent pneumothoraces 5 years earlier. Treatment with leuprolide was briefly administered. She smoked a few cigarettes daily and had no exposure to tuberculosis or toxins. Her family medical history was negative.

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