The treatment guidelines for pregnant women with OSA are similar to those for the general population, as the data in pregnant women are limited. An important goal in pregnant women is the avoidance of maternal hypoxemia. Patients with severe sleep apnea (apnea-hypopnea index [AHI], > 30), mild-to-moderate sleep apnea (AHI, 5 to 30) with clinical symptoms, or recurrent oxyhemoglobin desaturations of < 90% should receive treatment. Nasal continuous positive airway pressure (CPAP) is the first-line therapy. A small study showed that CPAP was safe and well tolerated in pregnant women. Oral appliances are impractical for use during pregnancy, in view of the multiple sessions needed in a short period of time for the optimization of therapy. Owing to the increased surgical risk during pregnancy, tracheostomy and uvulopalatopharyngoplasty are not routinely performed. In pregnant women with preexisting OSA, symptom recurrence should be assessed, especially if there is excess weight gain or gestational hypertension. Repeat polysomnogram or the titration of CPAP pressure is indicated if insufficient treatment is suspected.