On a personal note, I have known Professor O’Byrne for 30+ years. He has always served as an inspirational role model for me. During my formative years, I was a bit of an “oddball” in that I began my career by doing primarily human-based research studies. Not so many folks were as committed to that area as I was, yet Professor O’Byrne was. Indeed, he was successful at it! He always was, and is, willing to lend an ear to my current struggles, whatever they are, and offer guidance. He is never condescending and, if anything, his humility is in itself inspirational. I truly believe that the advice he offers in his video that you do not have to be brilliant but you do need persistence to be a successful medical researcher is one of the most important pieces of advice any junior investigator can hear. Obviously, if you are reading this commentary, it is likely you are “well above average” in intelligence, and Professor O’Byrne is most likely in the upper tiers of intelligence. However, his humility and humanity shine through in comments like these and make them all the more meaningful. Paul is indeed a genuine human being who loves global politics, golf, and good food (and wine) and has great stories to tell along the way.