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Original Research: Pulmonary Physiology |

Validation of the Exhaled Breath Temperature Measure: Reference Values in Healthy Subjects

Giovanna E. Carpagnano, MD, PhD; Maria P. Foschino-Barbaro, MD; Corrado Crocetta, MD; Donato Lacedonia, MD, PhD; Valerio Saliani, MD; Luigi Davide Zoppo, MD; Peter J. Barnes, MA, DM, DSc
Author and Funding Information

FUNDING/SUPPORT: The authors have reported to CHEST that no funding was received for this study.

aDepartment of Medical and Surgical Sciences, Institute of Respiratory Diseases, University of Foggia, Italy

bSection of Statistics, Faculty of Economics, University of Foggia, Italy

cAirway Disease Section, National Heart and Lung Institute, Imperial College London, Royal Brompton Hospital, London, UK

CORRESPONDENCE TO: Giovanna E. Carpagnano, MD, PhD, Department of Medical and Surgical Sciences, Institute of Respiratory Diseases, University of Foggia, D'Avanzo Hospital, Via degli Aviatori, 71100 Foggia, Italy


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2017;151(4):855-860. doi:10.1016/j.chest.2016.11.013
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Background  Exhaled breath temperature (EBT) is a new noninvasive method for the study of inflammatory respiratory diseases with a potential to reach clinical practice. However, few studies are available regarding the validation of this method, and they were mainly derived from small, pediatric populations; thus, the range of normal values is not well established. The aim of this study was to measure EBT values in an Italian population of 298 subjects (mean age, 45.2 ± 15.5 years; 143 male subjects; FEV1, 97.2% ± 5.8%; FVC, 98.4% ± 3.9%) selected from 867 adult volunteers to define reference values in healthy subjects and to analyze the influence of individual and external variables on this parameter.

Methods  EBT was measured with an X-halo PRO device to different ambient temperature ranging from 0°C to 38°C.

Results  We report reference values of EBT in healthy white subjects who had never smoked. EBT values were strongly influenced by the external temperature and to a lesser extent according to sex.

Conclusions  In a large population of healthy subjects who never smoked, these data provide reference values for measuring EBT as a basis for future studies. Our results are contribute to the promotion of EBT from “bench” to “bedside.”

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